Gene Expression

The Gene Expression Group at SHGC studies a number of interesting human phenotypes and complex diseases at the level of gene expression. We apply high-throughput methods to measure transcript levels, aiming to characterize the biological phenotypes efficiently, quantitatively, and on a genome-wide scale.

Our current research areas include:

Analysis of gene expression changes in human brains associated with major depression, bipolar disorder and schizophrenia

Study of natural variation and genetic influence of gene expression in cell lines from genetically related people such as twins, sibs, and parents

Comparison of gene expression patterns between human and chimpanzee lymphoblastoid cells

Technical development related to our projects, including microarray methods, RT-PCR, Serial Analysis of Gene Expression, and new methods for integrative data analysis, such as sample classification, multiple testing correction, and pathway analysis.